Aminomethylated Polystyrene HL (100–200 mesh) is a versatile solid-phase resin widely used in peptide synthesis, particularly in Boc-based solid-phase peptide synthesis (SPPS). Manufactured by Novabiochem®, this resin serves as a foundational support for constructing peptide chains, offering flexibility and efficiency in various synthetic applications.
Key Features
Resin Type: Polystyrene cross-linked with 1% divinylbenzene (DVB)
Functional Group: Primary amine (-CH₂NH₂)
Mesh Size: 100–200 mesh
Loading Capacity: Approximately 0.50–1.50 mmol/g
Appearance: White to yellow to beige beads
Swelling Volume: Lot-specific (typically measured in DMF)
Storage Temperature: 2–30 °CAmerican Chemical Suppliers+2Sigma Aldrich B2B+2MilliporeSigma+2MilliporeSigma
Applications
Aminomethylated Polystyrene HL resin is particularly suited for:
Boc-Based SPPS: Facilitates the synthesis of peptides using Boc chemistry, allowing for the introduction of various linkers and protecting groups.
Custom Linker Attachment: The primary amine functionality enables the attachment of carboxylic acid-containing linkers, providing flexibility in designing peptide synthesis strategies.
Solid-Phase Organic Synthesis (SPOS): Beyond peptides, this resin can be employed in the synthesis of small organic molecules, benefiting from its robust chemical stability.American Chemical Suppliers+1MilliporeSigma+1
Technical Specifications
Polymer Matrix: Copolymer of styrene and 1% DVB
Functional Group: Primary amine (-CH₂NH₂)
Loading Capacity: 0.50–1.50 mmol/g (determined using Fmoc-Leu substitution)
Mesh Size: 100–200 mesh
Swelling Volume: Lot-specific; optimized for solvents like DMF
Storage Conditions: Store at 2–30 °C in a dry environmentBLDpharm+1Peptide+1Sigma Aldrich B2B+1MilliporeSigma+1
Availability & Pricing
Aminomethylated Polystyrene HL resin is available in various quantities. For example, a 100 g package (Product No. 8550200100) is priced at approximately $850.53 USD. Prices may vary based on supplier and region. For the most accurate and up-to-date pricing, it's recommended to consult authorized distributors or the manufacturer's website.Alkali Scientific
Documentation & Safety
Safety Classification: Classified as a combustible solid
WGK (Water Hazard Class): 1 (low hazard to water)
Safety Data Sheet (SDS): Available through Merck's official website
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